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Few products have captured public interest as fast as GLP-1 receptor-agonist weight-loss drugs. But one unforeseen consequence of their popularity has been to create what is, in effect, one of the biggest
Cytosolic LC3-I is conjugated with phosphatidylethanolamine to form LC3-II during the formation of autophagosomes
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This Review focuses on recent advances in our understanding of these complex processes and outlines remaining knowledge gaps that must be filled to enable the development of next-generation gut hormone–derived antiobesity therapies with improved efficacy and enhanced tolerability
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