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Parkinson’s Disease (AD) The pathological hallmarks of Parkinson’s disease (PD) are a loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SN), the presence of proteinaceous inclusions termed Lewy bodies and neurites [174], abnormal deposition of α-synuclein (α-syn), mitochondrial dysfunction, disruption of the homeostasis between autophagy and apoptosis, and motor impairments such as rest tremor, rigidity, and bradykinesia [175,176]

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Taking levothyroxine on an empty stomach, separate from food and other medications, remains the gold standard for optimal absorption regardless of GLP-1 use