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doi: 10.1038/s41572-025-00630-5

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Typical lipid changes with GLP-1 therapy include: Total cholesterol reduction: 2–8% LDL cholesterol reduction: 3–6% Triglyceride reduction: 10–15% HDL cholesterol: minimal change or slight increase These effects vary by agent, dose, population, and treatment duration, as shown in systematic reviews and meta-analyses