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Because metabolic regulation is distributed across multiple physiological systems—including endocrine tissues, liver, adipose tissue, and cardiovascular signaling pathways GLP-RT provides a useful experimental tool for studying how coordinated receptor activation affects systemic metabolic biomarkers and physiological signaling responses

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Due to the heterogeneity in the clinical presentation of PCOS, two well-validated murine models of PCOS 37,46,70 were used