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“We saw that many of our patients with PT had a diverticulum or were missing bone over the sigmoid sinus, which is just downstream from the transverse sinuses.” Because CT scans have shown that this sigmoid sinus dehiscence can cause PT, “we started doing operations to reconstruct the sigmoid sinus or reduce the diverticulum

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Total body-fat mass came down more than with placebo or the approved comparison medicine, which helped show that most of the weight change was fat rather than lean tissue