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Navigation of dietary preferences and intakes GLP-1s meaningfully impact total energy intake and food preferences through multiple mechanisms—an active area of investigation—including peripherally in the gut, centrally in multiple brain regions, and through diet-microbiome-brain interactions [133]
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Additionally, there was overexpression in animals that received semaglutide of multiple antioxidant enzymes, including manganese superoxide dismutase (MnSOD, 1.45-fold, p=0.003)
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