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Under severe inflammatory conditions such as sepsis, or when induced by exogenous lipopolysaccharide (LPS) administration, there is a systemic increase in GLP-1 that is dependent on IL-6 (111, 181)
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Most patients notice reduced appetite and early satiety within the first week of GLP-1 treatment, as the medication activates receptors in the hypothalamus that reduce hunger signals and increase feelings of fullness
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