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Efficacy analyses were performed on two sets: the full analysis set, defined as all unique randomized patients grouped according to the treatment assigned at randomization, thereby following the intent-to-treat principle, and an on-treatment analysis, defined as all exposed patients while they were receiving treatment (that is, had received at least one dose in the previous 35 d), grouped according to the treatment that they received
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The appetite suppression is strong enough that fasting may feel almost too easy—a sign to eat deliberately and measure intake rather than relying on hunger cues
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