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In the clinical trials, peripheral edema occurred in 1.2% of patients with type 2 diabetes mellitus treated with Awiqli
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Moreover, GLP-1R has been shown to be expressed in POMC neurons within the arcuate nucleus of the hypothalamus (ARC) [93], suggesting that melanocortin pathways may play a key role in the central control of thermogenesis, as happens with the feeding process [94]
