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Ibuprofen 400 mg every 6-8 hours as needed (max 1,200 mg daily) Naproxen 220 mg every 8-12 hours as needed (max 660 mg daily) NSAIDs reduce both pain and the underlying inflammatory cytokine activity Take with food to minimize GI irritation Limit NSAID use to 7-14 days during the inflammatory peak (Phase 2) A 2023 study in Pain Medicine (Rodriguez et al.) found that patients using scheduled ibuprofen (400 mg three times daily) during weeks 2-4 of GLP-1 therapy reported 52% less musculoskeletal discomfort than those using it only as needed