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Participants showed significant reductions in waist circumference, systolic and diastolic blood pressure, glycated hemoglobin, fasting glucose, insulin levels, and lipid profiles

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Once released, gut peptides can act locally on afferent neurons innervating the GI tract that signal to the caudal brainstem or enteric neurons, or they can enter the circulation to act on peripheral targets to regulate glucose and lipid metabolism (17)