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Design and characterization of a GLP-1 R agonist IgG TB59-2 Since none of the 13 IgG hits showed any agonist activity, we engineered a GLP-1 R agonist antibody (TB59-2) by linking the native GLP-1 7–36 peptide with a (G4S)x3 linker to the light chain N-terminal of a functionally inactive but GLP-1 R-specific binder, TB01-2 (Figure 9)
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