joint pain tirzepatide POS0209 IMPACT OF ON MUSCULOSKELETAL AND RISKY ANALGESIC USE AMONG NON-DIABETIC INDIVIDUALS WITH OVERWEIGHT OR OBESE BODY HABITUS: A PROPENSITY SCORE-MATCHED, ACTIVE COMPARATOR, NEW USER DESIGN STUDY glp 1 ras mechanism Months:3 Month exclude-ms-46954776887466

joint pain tirzepatide POS0209 IMPACT OF ON MUSCULOSKELETAL AND RISKY ANALGESIC USE AMONG NON-DIABETIC INDIVIDUALS WITH OVERWEIGHT OR OBESE BODY HABITUS: A PROPENSITY SCORE-MATCHED, ACTIVE COMPARATOR, NEW USER DESIGN STUDY glp 1 ras mechanism Months:3 Month exclude-ms-46954776887466

glp 1 ras mechanism Mechanisms of action of GLP-1RA A Comprehensive Review of the –

Metformin is a widely prescribed, first-line oral antidiabetic agent that acts primarily through activation of AMP-activated protein kinase (AMPK), a key regulator of glucose metabolism, insulin sensitivity, and inflammation 13,14

exclude-ms-46954776887466

Months:3 Month

Strategy 1: nutritional fortification (the foundation) This is the single most impactful intervention