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The US Food and Drug Administration (FDA) approval for weight management of the first-generation glucagon-like peptide 1 (GLP-1) receptor agonists (RA) liraglutide in 2014 followed by two more potent GLP-1 based therapies (GBT), semaglutide (GLP-1RA) in 2021 and tirzepatide (dual GLP-1/gastric inhibitory polypeptide RA) in 2023 [8,9] have led to a paradigm shift in the management of health conditions related to obesity
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Patients should be instructed to avoid touching multiple tablets when removing a single dose, as the moisture from hands could affect the remaining tablets
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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