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The addressable obesity patient population conservatively estimated at 800 million people globally with BMI above 30, and considerably more when including the overweight population with comorbidities that justify pharmacotherapy dwarfs the T2DM market
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Furthermore, an NK1R antagonist reduced the number of active dopaminergic neurons in the SN, which indicates that NK1R inhibition may also suppress the nigrostriatal pathway (Minabe et al., 1996)
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