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Analysis of subgroup of patients with HF in the EXSCEL trial revelaed that use of once-weekly exenatide reduced the risk of all-cause mortality in patient without HF (HR 0.79 [95% CI, 0.68–0.92]), while in patients with baseline HF no effect was observed (HR, 1.05 [95% CI, 0.85–1.29) (67)
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This is important because weight loss itself can reduce inflammation
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