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This is significantly less than the 15-25%+ average weight loss often seen with high-dose GLP-1s like semaglutide or tirzepatide
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The two act on unrelated receptor families: Retatrutide at the GLP-1, GIP, and glucagon receptors, and Melanotan II as a non-selective analogue of alpha-melanocyte-stimulating hormone at melanocortin receptors
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