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Metformin: Anchoring Potential in GLP-1 RA Care Journey
Postmortem studies have reported that PD patients exhibit a reduced expression of insulin receptors (49, 51) and additionally have revealed a raised IRS-1 pS312 expression within nigral dopaminergic neurons as compared to aged-matched controls (52, 53), symbolic of dysfunctional insulin signaling
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Crucially, we also differentiated between short-acting GLP-1 RAs, such as exenatide and lixisenatide, which have immediate postprandial effects