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A small amount of GLP-1 may also be synthesized within the hypothalamus itself (11), and gut-derived GLP-1 may communicate with the brain by accessing GLP-1Rs within fibers innervating the portal vein or the nodose ganglion of the abdominal vagus nerve
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Evaluating Glycemic Control Efficacy and Safety of the Oral Small Molecule Glucagon-Like Peptide 1 Receptor Agonist Danuglipron in Type 2 Diabetes Patients: A Systemic Review and Meta-Analysis
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