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The study also indicated that GLP-1 RA treatment was associated with a moderately increased risk of gallstones (RR: 1.27, 95% CI 1.10–1.47), cholecystitis (RR: 1.36, 95% CI 1.14–1.62), and overall gallbladder disease risk (RR: 1.55, 95% CI 1.08–2.22) compared to placebo