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Most of this weight loss occurs within the first 68 to 72 weeks of treatment, so patience and consistency are key
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Subsequent trials testing higher doses found minimal additional benefit: 1,000 mg daily : HbA1c reduction of approximately 1.0 to 1.5% from baseline (Garber et al., Diabetes Care 2020) 2,000 mg daily : HbA1c reduction of approximately 1.5 to 1.8% 2,550 mg daily : HbA1c reduction of approximately 1.6 to 1.9% The difference between 2,000 mg and 2,550 mg is 0.1 to 0.2%, which is smaller than the inter-assay variability of HbA1c testing
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