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Peripherally circulating GLP-1 (143) and some GLP-1RAs, such as liraglutide and semaglutide (145), can readily access the CVOs, including the subfornical organ and the area postrema, which express GLP-1R and have close neuroanatomical connections with hypothalamus involved in forage and satiety control
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Obesity prevalence in the Medicare population is 35.5 percent (based on CDC data and CMS chronic conditions data), yielding 23.96 million obese beneficiaries
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