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Frontiers | A decade of progress in type 2 diabetes and cardiovascular disease: advances in SGLT2 inhibitors and GLP-1 receptor agonists – a comprehensive review
Long term data beyond five years is still limited, but current evidence does not suggest major bone health concerns
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The most plausible explanation is the glucagon arm, which is the one thing retatrutide has that the others don't — and if that's right, it may be an unavoidable cost of the mechanism rather than something you can engineer away
