semaglutide heart rate variability and health behavior responses to GLP-1 receptor agonists: a 12-wk study using wearable technology and causal inference | American Journal of Physiology-Heart and Circulatory Physiology VOL.U.LIFT™ GLP-1 4D Skin Subscription:1 month Parent:Lighting

semaglutide heart rate variability and health behavior responses to GLP-1 receptor agonists: a 12-wk study using wearable technology and causal inference | American Journal of Physiology-Heart and Circulatory Physiology VOL.U.LIFT™ GLP-1 4D Skin Subscription:1 month Parent:Lighting

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Furthermore, loss of lean muscle mass, which can occur alongside fat loss if protein intake and resistance exercise are inadequate, further reduces metabolic heat production since muscle tissue is metabolically active and generates significant body heat even at rest

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The authors noted this is an off-label strategy and called for controlled trials to validate effectiveness and define who might benefit