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And this regulatory effect was ineffective in Glp1r −/− mice, indicating that the immunoregulatory and anti-inflammatory effects of liraglutide depended on the GLP-1R signaling pathway ( high ) and monocytes (Clec12a + ) in the central nervous system (CNS), while decreasing the number of effector/memory T cells (CD4 + CD44 + ) and inhibiting inflammation in peripheral circulation and CNS ( Figure 3 ) ( Figure 3 Early immune cell infiltration in rodent stroke is dominated by neutrophils and macrophages/microglia, whereas in human ischemic stroke it is different, consisting mainly of neutrophils and T cells ( + T cells enriched more than 40-fold from the human body ( + T cells under Treg polarization conditions, and the proportion of GLP-1R + cells could reach 29-34%

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Meals per week:14

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