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Tapering Off of GLP-1s: A Gentle Exit Lowering your dose in small steps (from 2.4 mg of semaglutide to 1.7 mg, then to 1.0 mg) allows your hunger hormones and metabolism to adjust gradually to the changes in your body and brain

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[2] [3] GIP also augments glucose-dependent insulin secretion, though its effects on appetite and gastric emptying are more context-dependent and may be influenced by co-agonism with GLP-1