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In PIONEER 6, acute pancreatitis was identified in one patient treated with semaglutide, compared to three patients treated with placebo [16]
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Semaglutide was also the only drug to display significant ROR for throat tightness (1.69) and throat irritation
![Cardiovascular disease continuum-GLP-1 action. Adapted from [46]](https://www.researchgate.net/publication/357072789/figure/fig1/AS:1146405179654167@1650335702879/Cardiovascular-disease-continuum-GLP-1-action-Adapted-from-46.png)
