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This upstream mechanism means Tesamorelin works through the body’s natural GH/IGF-1 axis rather than bypassing it, which is why it produces measurable increases in both growth hormone and IGF-1 levels, in contrast to AOD-9604’s more targeted, IGF-1-sparing profile

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Understanding GLP-1 agonists means grasping not just their mechanism, but how individual factors—genetics, biomarkers, metabolic profile, and medical history—may influence treatment suitability and response