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In a phase II trial, adults with a BMI of ≥30 or ≥27 kg/m² with comorbidities were randomized to receive efpeglenatide at doses of 4 mg weekly, 6 mg weekly, 6 mg biweekly, or 8 mg biweekly, or a placebo, all combined with a hypocaloric diet [17]
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This rapid metabolic downshift can trigger temporary fluid imbalances and electrolyte depletion, particularly sodium and potassium
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