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Yet, it is notable that increased weight circumference, mid-life adiposity, and metabolic syndrome (all allied to peripheral IR and systemic inflammation) are associated with an elevated risk of PD (67–69)
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These interactions are further complicated by metabolic conditions such as obesity and diabetes, where hormonal resistance (e.g., leptin, insulin) and neurotransmitter dysregulation contribute to altered taste preferences and compulsive eating behaviors
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