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Before adding any new pain medication—prescription, over-the-counter, or herbal—inform your provider that you are on semaglutide or another GLP-1 medication
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With a sulfonylurea (a type of diabetes pill that lowers blood sugar), SURPASS-4 (Del Prato et al., Lancet 2021) reported hypoglycemia below 54 mg/dL in roughly 10 to 14% of tirzepatide users on the combination (9.9% at 10 mg, 12.8% at 15 mg, 13.8% at 5 mg) over up to 104 weeks
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