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In mammalian cells, mitochondrial ROS accumulation and lipids oxidation seem to play a key role in autophagy, since both O 2 • - and H 2 O 2 could induce autophagy [7]

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On Wegovy's FDA label, roughly 73% of patients report some gastrointestinal reaction versus 47% on placebo, with nausea in about 44%, diarrhea in 30%, constipation in 24%, vomiting in 24%, and abdominal pain in 20%