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In our model, Gly-10* of GLP-1 interacts with Leu-384 7.38 , just one helical turn below Arg-380 7.34 and therefore an Arg at ligand position 4* could easily reach the Asp substitution at position 380 7.34 , validating the choice of GLP-1 conformation based on PACAP21/1GEA (Figure 6A)