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The preference for injectable formulations is further supported by their ability to provide consistent drug levels, reducing the frequency of administration and enhancing patient compliance
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104 The most common side effect for both GLP-1RAs and metformin is moderate gastrointestinal discomfort, which can be soothed by gradual dose titration, eating small portions meals but with a higher frequency, and avoiding some compounds, including stimulant or secretory substances (caffeinated beverages, spices) and those known to cause relaxation of lower esophageal sphincter (fatty, fried or processed foods, chocolate, tomato, mint)
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