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Introduction# Retatrutide and survodutide represent two next-generation approaches to obesity and metabolic disease treatment that go beyond single-target GLP-1 receptor agonism
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Other companies, including Terns Pharmaceuticals (TERN-601), Structure Therapeutics (GSBR-1290), and Viking Therapeutics, have oral GLP-1 programs at earlier stages of development, but none has reached Phase 3 or generated the depth of clinical data available for orforglipron
