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Any Adverse Events, Serious Adverse Events, AE Withdraw and Hypoglycemia Events Liraglutide 3.0 mg significantly increased the incidence of any adverse events compared to semaglutide 2.4 mg (OR = 1.53, 95% CI [1.00, 2.34]), tirzepatide 10 mg (OR = 1.64, 95% CI [1.05, 2.56]) and tirzepatide 15mg (OR = 2.00, 95% CI [1.28, 3.12]) (Figure 3A)

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Among the significant metabolites, amino acids valine (FC = 1.22, pcorr = −0.43, VIP = 1.08), isoleucine (FC = 1.17, pcorr = −0.42, VIP = 1.12), and Hex2Cer d18:1/14:0 (FC = 1.32, pcorr = −0.42, VIP = 2.10) were elevated, whereas di–and tri–acylglycerols (FC = 0.58–0.80) were decreased in nFPG compared with NGT