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Osteocytes secrete sclerostin in response to mechanical stress, which acts on the Wnt/β-catenin pathway in osteoblasts to inhibit cell proliferation, impair mineralization, enhance apoptosis, and promote osteoclast formation and activity in a RANKL (receptor activator of nuclear factor κB (NF-κB) ligand)-dependent manner (Horwood, 2016)

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For adults, diabetes is an incredibly common diagnosis