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For patients with very large weight loss goals, tirzepatide may be favored on the basis of larger mean percent weight loss seen in pivotal trials, while semaglutide remains an effective weekly option with strong randomized trial support SURMOUNT-1 report If diabetes management is a major concern, individualize the choice to optimize both glycemic and weight outcomes and involve endocrinology when needed
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this combination of techniques may give refined spatial resolution (83, 84)
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