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A separate 12-week trial at 30mg showed an average loss of 8.1 kilograms, with 95.8 percent of participants achieving at least 5 percent body weight loss
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However, tirzepatide was significantly and independently associated with new onset of PDR, with the majority of events occurring in individuals with mild NPDR with maculopathy (R1M1) or moderate-to-severe NPDR with maculopathy (R1M1 or R2M1)
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