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Semaglutide (weekly injectable) Dosing frequency: Once weekly, same day each week Half-life: approximately 7 days (165 to 184 hours) Peak concentration: 1 to 3 days after injection Recommended timing approach: Most flexible of all GLP-1 formulations due to the long half-life

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Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models