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Because full-dose GLP-1 therapy can be difficult to tolerate long term, microdosing is being explored as a way to maintain consistent neurotrophic signaling over years rather than months—potentially supporting brain resilience, mitochondrial health, and cognitive longevity

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From the National Prescription Registry, we obtained the Defined Daily Doses (DDD) variable, which is based on “the assumed average maintenance dose per day for a drug used for its main indication in adults”, according to the World Health Organization Collaborating Centre for Drug Statistics Methodology ( Of note, exposure to metformin, the exposure drug, and the control drug was assumed to be continuous between initiation and end-of-treatment