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Overview of the Phase 2 NEJM Trial Design and Participants The phase 2 trial was a randomised, double-blind, placebo-controlled, dose-ranging study enrolling 338 adults with obesity or overweight without type 2 diabetes, assessing retatrutide doses of 1 mg, 4 mg, 8 mg, and 12 mg over 48 weeks

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Subgroup analyses examined the impact of sex, type 2 diabetes, previous GLP‐1 use, and history of bariatric surgery