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Rosenstock predicts that orforglipron and other similar small-molecule pills will eventually form the backbone of mainstream diabetes treatment, a role played today by the older glucose-lowering drug metformin: “I can see these molecules as a first-line therapy,” he says, prescribed to patients “from day one.” New Treatment Targets Drug developers are also racing to devise medications that drive even greater weight loss and offer more comprehensive overall health benefits, primarily by testing new agents that affect more than just the GLP-1 hormone receptor
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