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Beyond weight loss: GLP-1 emerges as a disease-modifying signal in osteoarthritis - Osteoarthritis and Cartilage
The GLP-1R are expressed in tissues other than pancreatic islets 24 , as in hepatocytes, but studies suggest that certain actions of GLP-1 in hepatic glucose metabolism occur through mechanisms that are independent of GLP-1R, and no alternative route seems to have been fully elucidated 25
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They bind to and activate GLP-1 receptors, helping to regulate appetite, blood sugar, and digestion
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