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GLP-1 receptor activation engages cyclic AMP-dependent signalling, protein kinase A, EPAC pathways and downstream anti-inflammatory and vasodilatory programmes (16–20)
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A versatile collection of pyrimidine-2,4-diones has been reported as DPP-4 inhibitors, with trelagliptin, linagliptin, and alogliptin being well-established members of this group