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Collectively, we uncovered a link between hepatic T3 action and glucose homeostasis through GLP-1, and provided evidence to show that the promising results observed for the liver-targeted TRβ agonist were not secondary to the known beneficial effects of weight loss on insulin sensitivity

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Genetic predispositions do not predict exact medication response, but they may reveal whether you have favorable receptor pathways (suggesting lower-cost, lower-dose options may work well) or less favorable variants (suggesting dual-agent or higher-dose compounds may offer better clinical return on investment)