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This interaction has been confirmed clinically: in renal transplant recipients, 0.2 g berberine three times daily for three months increased cyclosporine AUC by ∼34.5 % and prolonged its half-life by 2.7 h [150,151], while in heart transplant patients, a ∼25 % increase in cyclosporine blood levels was observed [152]
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It is important to follow the dose escalation plan provided by your prescriber to allow your body to adjust safely over time
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