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Like the injectable version, treatment requires gradual dose escalation through four levels (1.5mg, 4mg, 9mg, and 25mg) to manage side effects
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However, plasma concentrations of semaglutide at steady state are estimated to be about 100 times lower than the IC 50 values for OATP1B1/3 (3.50 μM and 2.95 μM, respectively)
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