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Whilst attractive as a theory, it should, nevertheless, be borne in mind that the majority of the studies cited above have been carried out in rodents or have examined isolated islets/α-cells under in vitro or ex vivo conditions, and whether a local pancreatic DPP-4/GLP-1 system plays an important role in normal human physiology or in the pharmacological effect of DPP-4 inhibitors is not clear

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To reduce rubber particulate in future vials, use a larger-gauge needle (18-gauge) for reconstitution and puncture the stopper in the center, not near the edge