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For all trials, the primary endpoints are percentage change from baseline at randomization (note that this was from week 20 in STEP 4) to end of treatment (EOT) in body weight and ≥ 5% WL from baseline after EOT (not applicable for the sustained WM trial [STEP 4])
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This allows them to bypass metabolism by hepatic enzymes such as CYPs or UDP-glucuronosyltransferases (UGTs)
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